Wetland ecosystems are the most important and prolific natural methane (CH4) sources. CH4 is constantly flowing in and out of these regions (flux), and that flow periodically fluctuates. Methanogens (methane producers) and methanotrophs (methane consumers) are microorganisms that influence CH4 fluxes in wetlands. However, the mutual, or symbiotic relationship between methanogens and methanotrophs remains unclear. Biologists and atmospheric scientists see a critical opportunity to explore methanogen and methanotroph population co-occurrence patterns and their influences on natural CH4 fluxes.