Fusarium oxysporum is a soil-borne fungal pathogen that causes a group of serious plant diseases known as Fusarium wilts. As one of the most economically important plant pathogens worldwide, it can infect hundreds of species—including major crops like tomatoes, bananas, cotton, and melons—causing wilting, stunting, and plant death. Understanding how F. oxysporum overcomes host defenses to increase pathogenicity is critical to mitigating its agricultural impact.